Smoking modulates different secretory subpopulations expressing SARS-CoV-2 entry genes in the nasal and bronchial airwaysArticle Published on 2022-10-282022-11-16 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 치료기술, [키워드] ACE2 airway airway epithelium airways association C15orf48 cell population changes in characterized club co-expressed cohorts CTSL diagnostic workup disease severity elevated epithelial cells expressed expressing expression expression data Gene Expression gene expression pattern Goblet cell increase in indicated individual Infection lung cancer lung cancer risk modulate modulated nasal Population SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection scRNA-seq secretory cell severe disease significantly similarity smoker smoking smoking status subpopulation TMPRSS2 viral entry Viral load [DOI] 10.1038/s41598-022-17832-6 PMC 바로가기
The interplay between the airway epithelium and tissue macrophages during the SARS-CoV-2 infectionArticle Published on 2022-10-062022-11-15 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료제, [키워드] 3D cultures activate added Air-liquid interface air-liquid interface (ALI) airway airway epithelium Antigen presentation antiviral immune response basolateral side cell type co-culture Contact Course Culture cytokine production cytokine release demonstrated driven by epithelial epithelial cells evaluate HAE hMDM hMDMs Human airway epithelium human airway epithelium (HAE) human monocyte-derived macrophage immune response in viral infected cell Infection Innate immunity lung Macrophage macrophages macrophages. phagocyte primary human airway recruitment Replication SARS-CoV-2 SARS-COV-2 infection Spread the SARS-CoV-2 tissue macrophage transfer virus virus replication [DOI] 10.3389/fimmu.2022.991991 PMC 바로가기
A lipid nanoparticle platform for mRNA delivery through repurposing of cationic amphiphilic drugsResearch article Published on 2022-10-012022-10-05 Journal: Journal of controlled release : official journal o [Category] 신약개발, [키워드] addition approach approval bovine CAD cancer cell cationic Cationic amphiphilic drugs Cationic lipid Cell Cellular delivery component Corneal COVID-19 mRNA vaccines drug drug combination Drug repurposing Efficiency encapsulation epithelial cell epithelial cells eyes functional healthcare HeLa cell in vitro in vivo Lipid lipid component Lipid nanoparticles Liposome LNP maintain Messenger RNA mRNA nanomedicine Patient pharmacological platform primary cell RNA RNA therapeutics selected small molecule drug subsequent Therapies Vesicle was obtained [DOI] 10.1016/j.jconrel.2022.08.009 [Article Type] Research article
NSP4 and ORF9b of SARS-CoV-2 Induce Pro-Inflammatory Mitochondrial DNA Release in Inner Membrane-Derived VesiclesArticle Published on 2022-09-232022-11-16 Journal: Cells [Category] SARS, 유전자 메커니즘, [키워드] airway epithelial cells anti-apoptotic approach BCl2 BCL2 antagonist/killer caused cell death cell-free mitochondrial DNA changes co-culture co-cultured COVID-19 COVID-19 patient Effect Effects epithelial cells functional induce inhibit Inner Interaction intercellular intercellular mitochondrial transfer knockdown MCL1 mechanism membrane vesicle mitigate mitochondrial mitochondrial DNA Mortality MSC MSCs myeloid cell myeloid cell leukemia-1 nsp4 Orf9b outer membrane overexpression plasma pro-apoptotic pro-inflammatory Protein Release reversed SARS-CoV-2 SARS-CoV-2 protein screened significantly stem cell therapeutic Therapeutic approach these cell transfer Treatment tunneling nanotubes. [DOI] 10.3390/cells11192969 PMC 바로가기
SARS-CoV-2 spike protein enhances MAP4K3/GLK-induced ACE2 stability in COVID-19Article Published on 2022-09-072022-10-06 Journal: EMBO Molecular Medicine [Category] COVID19(2023년), SARS, 진단, [키워드] ACE2 ACE2 protein cells contribute correlated COVID-19 COVID-19 cohort Degradation E3 ligase ENhance entry receptor epithelial epithelial cell epithelial cells Exosome Exosomes humanized Infection Live virus lysine MAP4K3/GLK mice overexpression pathogenesis of COVID-19 patients phosphorylated prevented pseudovirus infection residue RNA-sequencing SARS-CoV-2 SARS-CoV-2 pseudovirus SARS-CoV-2 spike SARS-CoV-2 spike protein secretion Serine serum exosome severity stability the SARS-CoV-2 transported UBR4 UBR4. Vesicle with COVID-19 [DOI] 10.15252/emmm.202215904 PMC 바로가기 [Article Type] Article
Anti-MDA5 dermatomyositis after COVID-19 vaccination: a case-based reviewCOVID-19 예방접종 후 항MDA5 피부근염: 사례 기반 검토Review Published on 2022-09-012022-09-12 Journal: Rheumatology International [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] activated administration characterized COVID-19 COVID-19 infection COVID-19 vaccine COVID-19 vaccines cytosolic dendritic cell dermatomyositis downstream epithelial cells erythematous Evidence high risk IFN individual inflammatory mediator Interstitial lung disease lesion literature review lung MDA5 MDA5. mRNA NAT Protein receiving replicate reported SARS-CoV-2 shown Trigger triggered type 1 interferon ulcerative vaccination Vaccine worldwide pandemic [DOI] 10.1007/s00296-022-05149-6 PMC 바로가기 [Article Type] Review
FASN inhibitor TVB-3166 prevents S-acylation of the spike protein of human coronavirusesArticle Published on 2022-09-012022-11-15 Journal: Journal of Lipid Research [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] acute respiratory syndrome Cell click chemistry conserved coronavirus CoV CoV-229E Critical cysteine de novo enzyme epithelial cells examined expressed FASN fatty Fatty acid host cell Host cell entry human coronavirus in vitro incubated Infection inhibited inhibitor isoform Modification modify Multiple other coronavirus palmitate phylogenetically Prevent Protein reduction in reported residues S-acylation SARS-CoV-2 specificity spike coronavirus. Spike protein Spread the spike protein ZDHHC ZDHHC5 [DOI] 10.1016/j.jlr.2022.100256 PMC 바로가기
Mesenchymal stem cell treatment for hyperactive immune response in patients with COVID-19COVID-19 환자의 과민성 면역 반응을 위한 중간엽 줄기세포 치료Review Published on 2022-09-012022-09-11 Journal: Immunotherapy [Category] COVID19(2023년), SARS, 변종, [키워드] Biomarker Biomarkers clinical clinical immunology clinical trials COVID-19 COVID-19 mortality COVID-19 patients CRP Cytokines decrease Effect effective Endothelitis epithelial cells Human immune system IL-6 immune response immune system independent invasive mesenchymal stem cell Mesenchymal stem cells mesenchymal stem cells. MSC MSC therapy MSCs organism patients with COVID-19 potential treatment option pro-inflammatory cytokine pro-inflammatory cytokines PROTECT reduction in regenerative regimen reported Respiratory failure Safe sick stem cell stem cells systemic systemic effects therapy Treatment Trial [DOI] 10.2217/imt-2021-0245 PMC 바로가기 [Article Type] Review
Bimodal distribution pattern associated with the PCR cycle threshold (Ct) and implications in COVID-19 infectionsPCR 주기 역치(Ct)와 관련된 바이모달 분포 패턴 및 COVID-19 감염에 미치는 영향Article Published on 2022-08-252022-09-11 Journal: Scientific Reports [Category] SARS, 변종, 진단, 치료기술, [키워드] 2019-nCoV age bimodal bimodal distribution cell types Chain Reaction Characteristics clinical sample clinical samples Combination Control COVID-19 COVID-19 infection COVID-19 pandemic Ct values cycle threshold disease control Disease progression dissemination distribution DNA epithelial cells examined explain Gender Genome heterogeneity host response implication Infection infection control Integrated DNA Technologies mucosal notable PCR PCR cycle platform polymerase chain reaction positive prevention ranged real-time RT-PCR respiratory respiratory epithelial cells RT-PCR sample collection SARS-CoV-2 stratified TaqPath ThermoFisher Scientific threshold Transmissibility Transmission Viral Viral load viral replication viral variant Viral variants [DOI] 10.1038/s41598-022-18735-2 PMC 바로가기 [Article Type] Article
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection by Intranasal or Intratesticular Route Induces Testicular Damage비강 또는 고환 경로에 의한 중증 급성 호흡기 증후군 코로나바이러스 2(SARS-CoV-2) 감염은 고환 손상을 유발합니다Article Published on 2022-08-242022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 변종, 신종인플루엔자, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Apoptosis asymmetric Awareness caused Cell change changes convalescent coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 damage death decrease degeneration delta variant demonstrated Depletion Disruption epididymal epithelial cells expressing hamster hamsters hemorrhage histopathological hypogonadism immune complex immunological change induce Infection Inflammation Influenza Influenza virus injection interstitial cell interstitial cells intranasal investigated Leydig cell Leydig cells lung tissues men Necrosis nucleocapsid omicron Pathogenesis Pneumonia prevented protein expression reduction in respiratory respiratory tract infection route SARS-CoV-2 SARS-CoV-2 nucleocapsid seminiferous Sertoli serum severe acute respiratory syndrome Coronavirus Sex sex hormone Sperm sperm count spermatogenesis spermatogenic cell spermatozoa subfertility subsequent testes testicle testicle. Testicular Testosterone vaccination variant Viral load viral loads Virological virus inoculum weight while wild-type SARS-CoV-2 worsening [DOI] 10.1093/cid/ciac142 PMC 바로가기 [Article Type] Article